Meeting Agenda

9:45   Arrive at the Institute

10:00  Introductions - Bonnie Rothberg

10:05  Kick-Off - Jonathan Rothberg

10:15  Tian Xu
            "Tsc1/Tsc2 function in the PI3K/Akt pathway and are inhibited by Akt phosphorylation"

10:30  John Blenis
            "The TSC1/TSC2 tumor suppressor complex antagonizes signaling by the nutrient sensor and cell size regulator mTOR"

10:45  Brendan Manning (Cantley Lab)
            "Biochemical and genetic analyses of the functional relationship between the PI3K signaling pathway and the TSC gene products"

11:00  Q&A

11:15  Bruce Taillon (CuraGen Corporation)
            "A proteomics approach for exploring the TSC1/2 pathway"

11:30  Amy Kiger (Perrimon Lab)
            "Functional genomics using RNAi screens in drosophila cells"

11:45  Lambert Edelmann (Hariharan Lab)
            "Setting up a cell-based assay in Drosophila for tuberous sclerosis"

12:00  Q&A

12:15  Lunch/ Tour of TRI


13:15  Lisa Henske
            "Pulmonary LAM: A Metastatic Mechanism?"

13:30  David Kwiatkowski
            "Advances in mouse models of TSC"

13:45  John Wheeler & Rachel Squillace (TRI)
            "Cell based screening for drugs to treat Tuberous Sclerosis"

14:00  Q&A

14:15  Tim Mitchison
            "Small molecule screening in academia "

14:30  Wolfgang Hinz (TRI)
            "Virtual Library Screening as a tool in modern drug discovery"

14:45  David Austin
            "Small molecule scaffolds as potential drug leads"

15:00  Q&A

15:15  Next Steps-Round Table Discussion

16:20  Concluding Remarks - Jonathan Rothberg

16:30  Moorings Restaurant - Appetizers & Cocktails

18:00   Adjourn

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