The Drug Design and Optimization Lab works to discover drug candidates against TSC targets. By simply downloading a non-intrusive software application, you can contribute the idle time available on your computer to fight against Tuberous Sclerosis Complex (TSC) even when not connected constantly to the Internet. This technology unites the vast power of participating computers with complex science to evaluate drug candidates capable of curing Tuberous Sclerosis Complex (TSC).

Simply stated, the (D2OL)™ software is downloaded to your personal computer and given drug candidates to evaluate. Once your computer receives tasks to execute, it begins a candidate evaluation process similar to finding the right key to fit into a lock. (D2OL)™ technology enables the process of sending hundreds of thousands of possible key combinations to all computing devices participating in the network and managing the results generated and returned to the network once you connect again to the internet. As a user, no intervention is required and the software executes as long as it is turned on, even when disconnected from the Internet. If interested, a very intriguing graphic user interface is provided for you.

By applying our tested platform which uniquely takes advantage of all available computing devices within its community including personal computers, servers and eventually devices like TiVo™ and the Xbox™, we are applying massive, cost-effective computing power to our discovery efforts. Using this computing power, our skilled methodology to identify targets (focusing on both drugability and the target's role in the disease) and collaborating with experts in computational chemistry and structure based drug design, the (D2OL)™ initiative is working to realize a 10 fold speed increase and 1,000 fold improvement in the accuracy of computer based drug discovery efforts.

Our Contribution

The Rothberg Institute process provides a major step forward in reducing the inefficiency and significant time involved in TSC drug discovery. The D2OL platform is being used to quickly and efficiently assemble significant computing power, scientific knowledge and key data required to accelerate necessary discovery critical in our fight against TSC.

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